Adrenoceptor Expression during Intervertebral Disc Degeneration
نویسندگان
چکیده
منابع مشابه
Intervertebral Disc Dynamics and Degeneration
Degenerative disc disease is a serious health problem worldwide, whose etiological basis – mechanical stimulus, biochemical changes, or natural aging – is poorly understood. While the disc’s known function is that of dynamic shock absorber, its dynamic response has not been fully characterized throughout the disc health spectrum (from healthy to degenerate). Therefore, this study aimed to corre...
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The intervertebral disc is a cartilaginous structure that resembles articular cartilage in its biochemistry, but morphologically it is clearly different. It shows degenerative and ageing changes earlier than does any other connective tissue in the body. It is believed to be important clinically because there is an association of disc degeneration with back pain. Current treatments are predomina...
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In this study, we used microarray analysis to investigate the biogenesis and progression of intervertebral disc degeneration. The gene expression profiles of 37 disc tissue samples obtained from patients with herniated discs and degenerative disc disease collected by the National Cancer Institute Cooperative Tissue Network were analyzed. Differentially expressed genes between more and less dege...
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As an intermediate filament protein, cytokeratin 8 (CK8) exerts multiple cellular functions. Moreover, it has been identified as a marker of notochord cells, which play essential roles in human nucleus pulposus (NP). However, the distribution of CK8 positive cells in human NP and their relationship with intervertebral disc degeneration (IDD) have not been clarified until now. Here, we found the...
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Degenerative spinal disorders including low back pain are one of the most common and costly problems for modern society. It has been recognized that these disorders are directly or indirectly associated with intervertebral disc degeneration. The disc is a cartilaginous connective tissue, composed of the nucleus pulposus(NP), annulus fibrosus and endplates, which connects adjacent vertebrae (the...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21062085